Could all the glute pain/tightening that keeps recurring be all in the head? There has been no evidence of pathology of any kind. The original symptoms were consistent with iron deficiency and there was initially a good response to iron supplementation. However, since that time it's all been about tight uncomfortable muscles (predominantly the glutes) that make running hard work. Where is that coming from? The brain is capable of much, could the brain be the source of these strange symptoms? Certainly the signs are consistent with neural dysfunction. Final diagnosis - head case. Treatment - try and retrain the brain.